Possible Interaction Between New Quinolones and Immune Functions in Macrophages

Gen Pharmacol. 1999 May;32(5):609-14. doi: 10.1016/s0306-3623(98)00243-2.

Abstract

Some of the immunological effects of a variety of new quinolones on chemotaxis and the production of superoxide anion in rat macrophages were studied. All of the new quinolones examined at a dose range of 0.5 to 50 microg/ml significantly inhibited chemotaxis in a dose-dependent manner in rat macrophages. Moreover, the new quinolones at a dose of 0.5 microg/ml were effective in markedly potentiating the generation of superoxide anion. These results indicate that the new quinolones may modulate immune functions in rat macrophages.

MeSH terms

  • Animals
  • Chemotaxis / drug effects
  • Chemotaxis / immunology
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Male
  • Quinolones / pharmacology*
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species / metabolism
  • Superoxides / metabolism

Substances

  • Quinolones
  • Reactive Oxygen Species
  • Superoxides