Oestrogen attenuates post-exercise myeloperoxidase activity in skeletal muscle of male rats

Acta Physiol Scand. 1999 Jun;166(2):85-90. doi: 10.1046/j.1365-201x.1999.00556.x.


The effects of 2 weeks of oestrogen (40 microg kg BW-1 beta-estradiol 3-benzoate) injection on 24 h post-exercise myeloperoxidase (MPO) activities were determined in plantaris and soleus muscles and liver of sexually mature male and female rats. The treadmill running protocol (45-60 min, at 28 m min-1, 15% grade) induced significant elevations in muscle MPO activities 24 h post-exercise in male rats, while prior oestrogen administration to male rats eliminated the post-exercise elevations in muscle MPO activities. Female rats experienced no significant post-exercise elevations in muscle MPO activities. Hence oestrogen administration to male rats attenuated post-exercise muscle MPO activities to levels found in female animals. Liver MPO activities were not significantly affected by exercise, gender or oestrogen administration. Oestrogen may be a factor in diminishing 24 h post-exercise skeletal muscle leukocyte infiltration and inflammatory response in both male and female muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Estradiol / analogs & derivatives*
  • Estradiol / pharmacology
  • Female
  • Liver / drug effects
  • Liver / enzymology
  • Male
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / enzymology
  • Neutrophils / pathology
  • Peroxidase / metabolism*
  • Physical Conditioning, Animal / physiology*
  • Rats
  • Rats, Sprague-Dawley


  • estradiol 3-benzoate
  • Estradiol
  • Peroxidase