Mus and Peromyscus chromosome homology established by FISH with three mouse paint probes

Mamm Genome. 1999 Jul;10(7):730-3. doi: 10.1007/s003359901080.


Fluorescence-labeled DNA probes constructed from three whole house mouse (Mus domesticus) chromosomes were hybridized to metaphase spreads from deer mouse (Peromyscus maniculatus) to identify homologies between the species. Mus Chr 7 probe hybridized strongly to the ad-centromeric two-thirds of Peromyscus Chr 1q. Most of Mus 3 probe hybridized principally to two disjunct segments of Peromyscus Chr 3. Mus Chr 9 probe hybridized entirely to the whole Peromyscus Chr 7. Three Peromyscus linkage groups were assigned to chromosomes, based on linkage homology with Mus. The data also are useful in interpretation of chromosomal evolutionary history in myomorphic rodents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biological Evolution
  • Chromosome Mapping*
  • DNA Probes
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Muridae / genetics*
  • Peromyscus / genetics*
  • Species Specificity


  • DNA Probes