Postinjury neuropathic pain syndromes

Med Clin North Am. 1999 May;83(3):597-626. doi: 10.1016/s0025-7125(05)70126-7.


Pain is clearly one of the most daunting problems of modern medicine. Posttraumatic neuropathic pain syndromes are a major component of the clinical problem. Structural lesions affecting roots, nerves, the plexi, and central structures can be imaged noninvasively. The molecular biology of the intraneural cascades that cause sensitization of the central pain-projecting neurons of the dorsal horn and subsequent allodynia, hyperalgesia, and hyperpathia is a subject of intense inquiry. The role of the clinician in identifying and eliminating the source of the pain is crucial before the effects of excitotoxicity and central sensitization permanently alter the physiology of the central pain-projecting neurons and make treatment ineffectual.

Publication types

  • Review

MeSH terms

  • Brachial Plexus / injuries
  • Humans
  • Nerve Compression Syndromes / complications
  • Nerve Compression Syndromes / physiopathology
  • Pain / etiology*
  • Pain / physiopathology*
  • Peripheral Nervous System Diseases / complications*
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / physiopathology*
  • Reflex Sympathetic Dystrophy / etiology
  • Reflex Sympathetic Dystrophy / physiopathology
  • Wounds and Injuries / complications*
  • Wounds and Injuries / physiopathology