Current diagnosis and treatment of corneal ulcers

Curr Opin Ophthalmol. 1998 Aug;9(4):45-9. doi: 10.1097/00055735-199808000-00008.


Successful treatment for a corneal ulcer requires proper diagnosis and antibiotic selection. The management should be guided by the severity of the clinical presentation, the ophthalmologist's confidence in making the proper diagnosis of bacterial keratitis, and the level of trust in the antibiotic agents chosen for the causative organisms. Universal standards include pretreatment cultures and dual broad-spectrum fortified antibiotics. Recent changes in practice suggest that empirical monotherapy treatment with a fluoroquinolone antibiotic may be appropriate for certain cases of bacterial keratitis. This article reviews the various diagnostic methods and treatment options currently practiced in the ophthalmic community.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / isolation & purification
  • Cornea / microbiology
  • Cornea / pathology
  • Corneal Ulcer / diagnosis*
  • Corneal Ulcer / drug therapy*
  • Corneal Ulcer / microbiology
  • Diagnosis, Differential
  • Eye Infections, Bacterial / diagnosis*
  • Eye Infections, Bacterial / drug therapy*
  • Eye Infections, Bacterial / microbiology
  • Humans
  • Ophthalmic Solutions
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Ophthalmic Solutions