Depressive symptoms and occurrence of type 2 diabetes among Japanese men

Diabetes Care. 1999 Jul;22(7):1071-6. doi: 10.2337/diacare.22.7.1071.


Objective: To examine the relationship between depressive symptoms and the incidence of type 2 diabetes.

Research design and methods: In 1984, 2,764 male employees of an electrical company in Japan completed a self-administered questionnaire including the Zung Self-Rating Depression Scale (SDS). They were followed for the next 8 years, and 2,380 (86%) responded to the follow-up survey in 1992. During the follow-up survey, occurrence of type 2 diabetes was diagnosed according to World Health Organization criteria.

Results: A total of 41 cases of type 2 diabetes were identified during the 8-year follow-up survey. After controlling for other known risk factors for type 2 diabetes, a proportional hazard analysis indicated that subjects who had moderate or severe levels of depressive symptoms (> or = 48 on the SDS) at baseline had a 2.3 times higher risk of having type 2 diabetes at the follow-up survey than those who were not depressed (< or = 39 on the SDS) (P < 0.05).

Conclusions: Depressive symptoms may be associated with the onset of type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Depression / epidemiology*
  • Depression / psychology
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / psychology*
  • Follow-Up Studies
  • Humans
  • Incidence
  • Japan / epidemiology
  • Leisure Activities
  • Male
  • Middle Aged
  • Patient Dropouts
  • Personality Inventory
  • Surveys and Questionnaires