Prediction of neurological outcome after birth asphyxia from early continuous two-channel electroencephalography

Early Hum Dev. 1999 Jun;55(2):113-23. doi: 10.1016/s0378-3782(99)00010-9.


Objective: To determine whether two-channel continuous electroencephalography (EEG) applied within 12 h of birth can predict the severity of neurological complications and neurodevelopmental outcome following birth asphyxia.

Methods: A continuous two-channel EEG was performed within 12 h of birth in 22 infants suspected of having suffered birth asphyxia and 11 healthy control infants (22 infants at a general and 11 at a specialist paediatric unit). Criteria to categorise normal and abnormal EEG records were defined and compared with the severity of hypoxic/ischaemic encephalopathy (HIE) and with neurodevelopmental outcome, assessed at or after 12 months of age.

Results: EEG recordings were commenced at a median (range) of 2 h 50 min (1 h 45 min to 12 h) after birth. Technically satisfactory recordings were obtained in all but one infant. All control infants remained asymptomatic and had a normal EEG with discernible sleep/awake periods. 12 h after birth the EEG was normal in all 12 infants suspected of asphyxia who remained well or developed grade 1 HIE and was abnormal in six of nine infants with grade II or III HIE. Fifteen of 16 infants suspected of asphyxia with a normal neurodevelopmental outcome had a normal EEG at 12 h; transient abnormalities lasting not more than 8 h had been detected in three of these infants. All five infants who died or developed neurodevelopmental abnormalities had an abnormal EEG. At 12 h of age the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and likelihood ratio for predicting severe (grade II or III) HIE were: 67, 100, 100, 80% and infinity and for subsequent death or neurodevelopmental impairments: 100, 94, 83, 100 and 16%, respectively. Assessment of the EEG before 12 h of age altered prognostic accuracy: 4 h after birth the sensitivity, specificity, positive and negative predictive values and the likelihood ratio for poor neurodevelopmental outcome were 100, 71, 33%, 100 and 3.7%, respectively (16 infants).

Conclusion: Continuous two-channel EEG is an accurate tool for assessing the severity of neurological insult soon after birth asphyxia.

MeSH terms

  • Asphyxia Neonatorum / diagnosis*
  • Asphyxia Neonatorum / mortality
  • Asphyxia Neonatorum / physiopathology
  • Brain Ischemia / diagnosis*
  • Brain Ischemia / physiopathology
  • Electroencephalography / methods*
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Prognosis
  • Survival Rate
  • Time Factors