DNA recombination: the replication connection

Trends Biochem Sci. 1999 Jul;24(7):271-5. doi: 10.1016/s0968-0004(99)01413-9.


Chromosomal double-strand breaks (DSBs) arise after exposure to ionizing radiation or enzymatic cleavage, but especially during the process of DNA replication itself. Homologous recombination plays a critical role in repair of such DSBs. There has been significant progress in our understanding of two processes that occur in DSB repair: gene conversion and recombination-dependent DNA replication. Recent evidence suggests that gene conversion and break-induced replication are related processes that both begin with the establishment of a replication fork in which both leading- and lagging-strand synthesis occur. There has also been much progress in characterization of the biochemical roles of recombination proteins that are highly conserved from yeast to humans.

Publication types

  • Review

MeSH terms

  • DNA Damage
  • DNA Repair
  • DNA Replication*
  • Gene Conversion
  • Humans
  • Recombination, Genetic*