The Marks Asthma Quality of Life Questionnaire: further validation and examination of responsiveness to change

J Clin Epidemiol. 1999 Jul;52(7):667-75. doi: 10.1016/s0895-4356(99)00026-8.


We performed analyses to examine the structure, validity, and responsiveness to change of the Marks Asthma Quality of Life Questionnaire (AQLQ), originally validated in Australia in a self-administered format, among 539 U.S. subjects with asthma. Subjects were interviewed twice by telephone over an 18-month period. Based on factor analyses, the subscale structure of the AQLQ was modified slightly to eliminate item overlap among subscale scores. Cross-sectionally, total AQLQ scores were significantly correlated in expected directions with baseline asthma severity scores (r = 0.58), SF-36 physical (r = -0.66) and mental (r = -0.40) health status scores, and pulmonary function (FEV1% predicted, r = -0.14). Longitudinally, changes in AQLQ total and subscale scores were significantly (P<0.01) associated with changes in asthma severity and both physical and mental status. The AQLQ, administered by telephone, appears to be useful for assessing changes in the impact of adult asthma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • Asthma / classification*
  • Asthma / psychology
  • Cross-Sectional Studies
  • Female
  • Health Status
  • Humans
  • Male
  • Mental Health
  • Quality of Life*
  • Reproducibility of Results
  • Severity of Illness Index
  • Sickness Impact Profile
  • Surveys and Questionnaires*
  • United States