The changing landscape of ischaemic brain injury mechanisms

Nature. 1999 Jun 24;399(6738 Suppl):A7-14. doi: 10.1038/399a007.


Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis
  • Brain Ischemia* / etiology
  • Brain Ischemia* / pathology
  • Brain Ischemia* / therapy
  • Calcium / metabolism
  • Forecasting
  • Humans
  • Potassium / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Thrombolytic Therapy
  • Zinc / toxicity


  • Receptors, N-Methyl-D-Aspartate
  • Zinc
  • Potassium
  • Calcium