Emerging insights into the genesis of epilepsy

Nature. 1999 Jun 24;399(6738 Suppl):A15-22. doi: 10.1038/399a015.


Epilepsies are a diverse collection of brain disorders that affect 1-2% of the population. Current therapies are unsatisfactory as they provide only symptomatic relief, are effective in only a subset of affected individuals, and are often accompanied by persistent toxic effects. It is hoped that insight into the cellular and molecular mechanisms of epileptogenesis will lead to new therapies, prevention, or even a cure. Emerging insights point to alterations of synaptic function and intrinsic properties of neurons as common mechanisms underlying the hyperexcitability in diverse forms of epilepsy.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / etiology
  • Axons
  • Brain Injuries / complications
  • Epilepsy / etiology*
  • Epilepsy / genetics
  • Epilepsy / therapy
  • Forecasting
  • Humans
  • Neurons / immunology