Successful treatment of oxidative stress in vitiligo

Skin Pharmacol Appl Skin Physiol. May-Jun 1999;12(3):132-8. doi: 10.1159/000029867.

Abstract

Patients with vitiligo have low catalase levels in their involved and uninvolved epidermis in association with high levels of hydrogen peroxide (H2O2). H2O2 has been confirmed for the first time in vivo using Fourier Transform Raman spectroscopy. A topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H2O2 in vitiligo. This approach leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder.

MeSH terms

  • Calcium / physiology
  • Calcium / therapeutic use
  • Catalase / metabolism
  • Catalase / therapeutic use
  • Combined Modality Therapy
  • Dose-Response Relationship, Radiation
  • Female
  • Homeostasis
  • Humans
  • Hydrogen Peroxide / metabolism
  • Male
  • Oxidative Stress / physiology*
  • Pteridines / metabolism
  • Skin / chemistry
  • Skin / enzymology
  • Ultraviolet Rays
  • Vitiligo / metabolism*
  • Vitiligo / therapy*

Substances

  • Pteridines
  • Hydrogen Peroxide
  • Catalase
  • Calcium