Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha

J Med Chem. 1999 Jul 1;42(13):2295-314. doi: 10.1021/jm980541n.

Authors

R C Newton¹, C P Decicco

Affiliation

¹ Departments of Inflammatory Diseases Research and Chemical and Physical Sciences, The DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500, USA.

PMID: 10395470
DOI: 10.1021/jm980541n

No abstract available

Publication types

Review

MeSH terms

Animals
Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
Cyclic AMP / biosynthesis
Drug Design
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / therapeutic use
Gene Expression Regulation
Humans
Metalloendopeptidases / antagonists & inhibitors
Receptors, Tumor Necrosis Factor / drug effects
Signal Transduction / drug effects
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / biosynthesis
Tumor Necrosis Factor-alpha / genetics
Tumor Necrosis Factor-alpha / metabolism

Substances

Enzyme Inhibitors
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha
Cyclic AMP
Calcium-Calmodulin-Dependent Protein Kinases
Metalloendopeptidases