Structure and function of the nucleolus

Curr Opin Cell Biol. 1999 Jun;11(3):385-90. doi: 10.1016/S0955-0674(99)80054-4.


The activity of the ribosomal RNA genes generates a distinct subnuclear structure, the nucleolus, which is the site of ribosome biogenesis. The signals that target proteins and snoRNAs (small nucleolar RNAs) to the nucleolus, the nuclear import of ribosomal proteins, the export of the completed ribosomal subunits and the molecular organization of the nucleolus have been the subject of intense research during the past year. Evidence is accumulating that nucleoli functionally interact with coiled bodies and are also involved in the maturation of non-ribosomal RNA species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleolus / physiology*
  • Cell Nucleolus / ultrastructure*
  • Humans
  • Nuclear Proteins / physiology
  • RNA, Small Nuclear / metabolism


  • Nuclear Proteins
  • RNA, Small Nuclear