Nuclear organization of pre-mRNA splicing factors

Curr Opin Cell Biol. 1999 Jun;11(3):372-7. doi: 10.1016/S0955-0674(99)80052-0.


The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Humans
  • RNA Precursors / genetics
  • RNA Precursors / metabolism*
  • RNA Splicing*
  • RNA, Small Nuclear / metabolism
  • Spliceosomes / metabolism*


  • RNA Precursors
  • RNA, Small Nuclear