Determinants of SR protein specificity

Curr Opin Cell Biol. 1999 Jun;11(3):358-62. doi: 10.1016/S0955-0674(99)80050-7.


The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are unique and are specific to a given family member. A number of studies during the past year have investigated the basis for SR protein specificity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • Humans
  • Nuclear Proteins / metabolism*
  • Phosphoproteins / metabolism*
  • Protein Binding
  • RNA Precursors / genetics
  • RNA Precursors / metabolism
  • RNA Splicing
  • RNA-Binding Proteins / metabolism*
  • Serine-Arginine Splicing Factors


  • Nuclear Proteins
  • Phosphoproteins
  • RNA Precursors
  • RNA-Binding Proteins
  • Serine-Arginine Splicing Factors