Regulation of back-propagating action potentials in hippocampal neurons

Curr Opin Neurobiol. 1999 Jun;9(3):288-92. doi: 10.1016/s0959-4388(99)80042-7.


Protein kinase C has recently been shown to modulate the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Moreover, dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase. The electrical signalling ability of these dendrites is thus highly regulated by a number of neurotransmitters and second-messenger systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Hippocampus / cytology*
  • Neurons / physiology*
  • Signal Transduction / physiology*