Calcium channelopathies in the central nervous system

Curr Opin Neurobiol. 1999 Jun;9(3):274-80. doi: 10.1016/s0959-4388(99)80040-3.


The recent discovery that familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6 are allelic disorders caused by different mutations in CACNA1A, a calcium-channel-encoding gene, adds to a growing list of channelopathies causing paroxysmal neurologic disturbance and progressive neurodegeneration. Calcium channelopathies in the central nervous system provide a model to study the important roles that calcium channels play in neuronal function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Channels / physiology*
  • Central Nervous System / chemistry
  • Central Nervous System / physiology*
  • Humans
  • Migraine Disorders / physiopathology*
  • Spinocerebellar Degenerations / physiopathology*


  • Calcium Channels