Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus

Curr Opin Neurobiol. 1999 Jun;9(3):299-304. doi: 10.1016/s0959-4388(99)80044-0.


Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel metabotropic L-glutamate receptors in hippocampal long-term potentiation and long-term depression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Chemistry / physiology
  • Hippocampus / physiology*
  • Long-Term Potentiation / physiology*
  • Receptors, Metabotropic Glutamate / physiology*
  • Synaptic Transmission / physiology


  • Receptors, Metabotropic Glutamate