The effect of once-daily latanoprost on intraocular pressure and pulsatile ocular blood flow in normal tension glaucoma

Eye (Lond). 1999:13 ( Pt 1):31-4. doi: 10.1038/eye.1999.6.


Purpose: To determine the effect of once-daily 0.005% latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in patients with normal tension glaucoma (NTG).

Methods: The diurnal IOP and sitting POBF were determined for 32 eyes of 19 NTG patients after a washout period. The subjects were treated with 0.005% latanoprost for 3-4 weeks and the measurements repeated. Statistical analysis was performed using the Wilcoxon signed rank test.

Results: Median IOP before and after treatment were 19 and 15 mmHg respectively (p < 0.001). The IOP reduction correlated with the initial IOP before treatment (p < 0.01) and was accompanied by an increase in median POBF from 656 to 796 microliters/min (p < 0.001).

Conclusions: Once-daily treatment with 0.005% latanoprost provides a significant and stable IOP reduction in the majority of NTG patients after short-term treatment. This is accompanied by a significant increase in POBF.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Topical
  • Aged
  • Circadian Rhythm
  • Drug Administration Schedule
  • Eye / blood supply*
  • Female
  • Glaucoma / drug therapy*
  • Glaucoma / physiopathology
  • Humans
  • Intraocular Pressure / drug effects
  • Latanoprost
  • Male
  • Prostaglandins F, Synthetic / therapeutic use*
  • Pulsatile Flow / drug effects


  • Prostaglandins F, Synthetic
  • Latanoprost