Can subretinal microphotodiodes successfully replace degenerated photoreceptors?

Vision Res. 1999 Jul;39(15):2555-67. doi: 10.1016/s0042-6989(98)00312-5.


The idea of implanting microphotodiode arrays as visual prostheses has aroused controversy on its feasibility from the moment it appeared in print. We now present results which basically support the concept of replacing damaged photoreceptors with subretinally implanted stimulation devices. Network activity in degenerated rat retinae could be modulated through local electrical stimulation in vitro. We also investigated the long term stability and biocompatibility of the subretinal implants and their impact on retinal physiology in rats. Ganzfeld electroretinograms and histology showed no significant side effect of subretinal implants on retinal function or the architecture of the inner retina.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials
  • Blindness / pathology
  • Blindness / rehabilitation*
  • Electronics, Medical / instrumentation*
  • Electroretinography
  • In Vitro Techniques
  • Light
  • Miniaturization
  • Prostheses and Implants*
  • Rats
  • Retina / pathology
  • Retinal Degeneration / pathology
  • Retinal Degeneration / rehabilitation*
  • Semiconductors
  • Time Factors


  • Biocompatible Materials