[Effect of protoporphyrin on digestive tract absorption of dioxins in rats]

Fukuoka Igaku Zasshi. 1999 May;90(5):162-70.
[Article in Japanese]

Abstract

This paper presents the fecal excretion of polychlorinated dibenzo-p-dioxin (PCDD) congeners, and polychlorinated dibenzofuran (PCDF) congeners in male rats fed a diet containing 0.5% disodiumprotoporphyrin (PPNa) or 0.5% hemin. The animals were administered 4 g of 0.5% PPNa or 0.5% hemin diet containing 0.5 ml of the causal rice-bran oil of Yusho that had occurred in the Southwest part of Japan in 1968 and kept on the same diet for five days. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with 0.5% PPNa were 2.1 and 1.9 times higher, respectively, than that in the group fed with a control diet. Hemin did not show any significant effect on the inhibition of absorption of dioxins. Next, the rats were given a diet containing 0.5% PPNa or 0.5% Hemin for four weeks after a week interval from the day of the causal rice-bran oil administration. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with 0.5% PPNa were stimulated 2.1 times higher, respectively, than that in the group fed with a control diet. Hemin did not show any significant effect on the inhibition of re-absorption of dioxins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzofurans / analysis
  • Benzofurans / pharmacokinetics*
  • Depression, Chemical
  • Feces / chemistry
  • Food Contamination
  • Hemin / pharmacology
  • Intestinal Absorption / drug effects*
  • Male
  • Oryza
  • Plant Oils
  • Polychlorinated Dibenzodioxins / analogs & derivatives*
  • Polychlorinated Dibenzodioxins / analysis
  • Polychlorinated Dibenzodioxins / pharmacokinetics
  • Polymers / analysis
  • Polymers / pharmacokinetics*
  • Protoporphyrins / pharmacology*
  • Rats
  • Rats, Wistar
  • Soil Pollutants / analysis
  • Soil Pollutants / pharmacokinetics*

Substances

  • Benzofurans
  • Plant Oils
  • Polychlorinated Dibenzodioxins
  • Polymers
  • Protoporphyrins
  • Soil Pollutants
  • polychlorodibenzofuran
  • Hemin