Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells

Immunol Lett. 1999 May 3;68(1):3-15. doi: 10.1016/s0165-2478(99)00024-3.


ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negatively regulate the activation of cells when co-crosslinked with ITAM containing receptors, illustrates the inhibitory processes by the negative regulation of B-, NK-, T-cells and mast cells and summarizes current views on the mechanism of ITIM-mediated inhibition.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphocyte Activation*
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism*
  • Mast Cells / immunology*
  • Mast Cells / metabolism*
  • Receptors, Immunologic / physiology*
  • Tyrosine / physiology*


  • Receptors, Immunologic
  • Tyrosine