Expression of hMSH2 correlates with in vitro chemosensitivity to CDDP cytotoxicity in oral and oropharyngeal carcinoma

Cancer Lett. 1998 Oct 23;132(1-2):37-44. doi: 10.1016/s0304-3835(98)00157-8.

Abstract

We investigated the expression of hMSH2, a human mutS homologue from chromosome 2p, in oral and oropharyngeal squamous cell carcinoma (SCC) by an immunohistochemical technique and performed tumor in vitro chemosensitivity testing. In 58 oral and oropharyngeal SCC, the hMSH2 positive score was inversely associated with tumor size, but not with other clinical parameters. Among five anticancer drugs (cisplatin (CDDP), 5-FU, peplomycin, mitomycin C and doxorubicin), only for CDDP was sensitivity to cytotoxicity correlated with the hMSH2 positive score. The susceptibility of hMSH2-positive tumors to CDDP killing was significantly higher than that of hMSH2-negative tumors. Immunohistochemical results regarding hMSH2 are promising in the evaluation of the sensitivity of cancer cells to CDDP cytotoxicity and enable one to select patients for adjuvant chemotherapy for oral and oropharyngeal SCC.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / pharmacology*
  • Carcinoma, Squamous Cell / classification
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / metabolism*
  • Cisplatin / pharmacology*
  • DNA-Binding Proteins*
  • Doxorubicin / pharmacology
  • Female
  • Fluorouracil / pharmacology
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mitomycin / pharmacology
  • Mouth Neoplasms / classification
  • Mouth Neoplasms / drug therapy
  • Mouth Neoplasms / metabolism*
  • MutS Homolog 2 Protein
  • Oropharyngeal Neoplasms / classification
  • Oropharyngeal Neoplasms / drug therapy
  • Oropharyngeal Neoplasms / metabolism*
  • Peplomycin / pharmacology
  • Proto-Oncogene Proteins / analysis
  • Proto-Oncogene Proteins / biosynthesis
  • Proto-Oncogene Proteins / drug effects*
  • Tumor Cells, Cultured / chemistry
  • Tumor Cells, Cultured / cytology
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Mitomycin
  • Peplomycin
  • Doxorubicin
  • MSH2 protein, human
  • MutS Homolog 2 Protein
  • Cisplatin
  • Fluorouracil