Loss of p120ctn in human colorectal cancer predicts metastasis and poor survival

Cancer Lett. 1998 Oct 23;132(1-2):193-201. doi: 10.1016/s0304-3835(98)00190-6.

Abstract

The p120ctn protein (formerly p120CAS) is an armadillo family member that associates directly with the cytoplasmic tail of E-cadherin and participates in the junctional complex responsible for cell-cell adhesion. Since reduced cell-cell adhesion is associated with metastasis in colorectal cancer and other neoplasms, we hypothesize that reduced expression of p120ctn may be related to metastasis in colorectal tumors. Here we describe a study of p120ctn expression in 44 primary human colorectal adenocarcinomas. As detected by immunohistochemical methods, we find altered p120ctn staining patterns in 86% of the cases. Regional complete loss of expression is seen in 18% of the cases, and it correlates with high stage disease and nodal metastasis as well as decreased survival. Although this is a preliminary study, it suggests that downregulation of p120ctn in colon cancer may be associated with metastasis and poor clinical outcome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Catenins
  • Cell Adhesion Molecules / analysis
  • Cell Adhesion Molecules / metabolism*
  • Colorectal Neoplasms / metabolism*
  • Colorectal Neoplasms / pathology
  • Disease-Free Survival
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Phosphoproteins / analysis
  • Phosphoproteins / metabolism*
  • Predictive Value of Tests
  • Prognosis
  • Survival Analysis

Substances

  • Catenins
  • Cell Adhesion Molecules
  • Phosphoproteins
  • delta catenin