Abstract
A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Transport / drug effects
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Cross-Linking Reagents / chemistry
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Dimerization
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Humans
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Polyamines / metabolism*
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Spermidine / analogs & derivatives*
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Spermidine / chemical synthesis*
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Spermidine / chemistry
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Spermidine / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Cross-Linking Reagents
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Polyamines
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norspermidine
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Spermidine