Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: in vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis

J Biomed Mater Res. 1999 Sep 15;46(4):494-503. doi: 10.1002/(sici)1097-4636(19990915)46:4<494::aid-jbm7>;2-e.


In this study, a novel antibiotic carrier system for use in the treatment of implant-related and chronic osteomyelitis was developed. Sulbactam-cefoperazone was introduced to rods of polyhydroxybutyrate-co-hydroxyvalerate (22 mol % HV, w/w), a member of a family of microbial-origin polymer that is biodegradable, biocompatible, and osteoconductive due to its piezoelectric property. The antibiotic-loaded carrier was implanted into the infection site that was induced by Staphylococcus aureus inoculation into the rabbit tibia. The effectiveness of this was assessed macroscopically, radiographically, bacteriologically, and histopathologically. Findings of infection subsided on day 15 and almost complete remission was observed on day 30. The control side that contained antibiotic-free rods, however, worsened. These findings prompted us to conclude that the novel biodegradable antibiotic carrier developed in the present study seems to be a promising candidate for use in the treatment of severe bone infection.

MeSH terms

  • Animals
  • Biocompatible Materials
  • Biodegradation, Environmental
  • Cefoperazone / administration & dosage*
  • Cefoperazone / therapeutic use
  • Drug Carriers
  • Drug Implants*
  • Drug Screening Assays, Antitumor
  • Drug Therapy, Combination / administration & dosage*
  • Drug Therapy, Combination / therapeutic use
  • Osteomyelitis / diagnostic imaging
  • Osteomyelitis / drug therapy*
  • Polyesters / administration & dosage*
  • Rabbits
  • Radiography
  • Staphylococcal Infections / diagnostic imaging
  • Staphylococcal Infections / drug therapy*
  • Sulbactam / administration & dosage*
  • Sulbactam / therapeutic use
  • Tibia


  • Biocompatible Materials
  • Drug Carriers
  • Drug Implants
  • Polyesters
  • poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate)
  • Cefoperazone
  • Sulbactam