The transition from hyperplasia to invasive carcinoma of the breast

J Pathol. 1999 Feb;187(3):272-8. doi: 10.1002/(SICI)1096-9896(199902)187:3<272::AID-PATH265>3.0.CO;2-2.


The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Breast / pathology*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Cell Transformation, Neoplastic
  • Female
  • Humans
  • Hyperplasia / genetics
  • Mice
  • Neoplasm Invasiveness
  • Precancerous Conditions / genetics*