Paraneoplastic painful ulnar neuropathy

Muscle Nerve. 1999 Jul;22(7):952-5. doi: 10.1002/(sici)1097-4598(199907)22:7<952::aid-mus24>3.0.co;2-j.

Abstract

A 58-year-old woman developed painful, bilateral ulnar neuropathy in conjunction with small cell lung carcinoma and high serum titer of anti-Hu antibody. An incidental stage I plasma cell dyscrasia, with immunoglobulin G kappa monoclonal protein, was also present. Electropysiological assessment excluded a generalized neuropathy, and nerve biopsy showed marked loss of myelinated and small unmyelinated fibers, without inflammatory changes or amyloid deposition. High titers of circulating anti-Hu antibody can be associated with symptoms resembling a paraneoplastic mononeuropathy.

Publication types

  • Case Reports

MeSH terms

  • Antibodies / blood*
  • Carcinoma, Small Cell / immunology*
  • Female
  • Humans
  • Lung Neoplasms / immunology*
  • Middle Aged
  • Neural Conduction
  • Neuralgia / immunology*
  • Paraneoplastic Syndromes / immunology*
  • Ulnar Nerve / physiopathology*

Substances

  • Antibodies