Prevalence and correlates of Capgras syndrome in Alzheimer's disease

Int J Geriatr Psychiatry. 1999 Jun;14(6):415-20. doi: 10.1002/(sici)1099-1166(199906)14:6<415::aid-gps929>;2-3.


Objectives: This study examined the prevalence and clinical correlates of Capgras syndrome (CS) in Alzheimer's disease.

Design: Cross-sectional study of elderly patients evaluated at an outpatient memory disorders clinic classified according to the presence or absence of CS.

Subjects: One hundred and fifty-one consecutive patients diagnosed with probable (N=110) or possible (N=48) Alzheimer's disease (AD) utilizing NINCDS-ADRDA diagnostic criteria.

Materials: The Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), Mini-Mental State Examination (MMSE) and Blessed Dementia Scale (BDS).

Results: CS was observed in 10% of the sample (N=16). Associated factors included other delusions, lower MMSE scores and higher BDS scores. The relation between CS and both cognitive and functional status remained significant after controlling for other delusions.

Conclusion: CS was prevalent in approximately 10% of our community-dwelling AD sample. This syndrome was more common at the later stages of the illness and showed relations with increased functional impairment and other psychotic symptomatology.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / epidemiology*
  • Capgras Syndrome / diagnosis
  • Capgras Syndrome / epidemiology*
  • Cognition Disorders / epidemiology
  • Cross-Sectional Studies
  • Delusions / epidemiology
  • Disease Progression
  • Female
  • Humans
  • Incidence
  • Male
  • Outpatients / statistics & numerical data*
  • Prevalence
  • Psychiatric Status Rating Scales