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Review
. 1999 May 28;843(1-2):247-74.
doi: 10.1016/s0021-9673(99)00153-3.

Clinical Applications of Gas Chromatography and Gas Chromatography-Mass Spectrometry of Steroids

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Review

Clinical Applications of Gas Chromatography and Gas Chromatography-Mass Spectrometry of Steroids

B G Wolthers et al. J Chromatogr A. .

Abstract

This review article underlines the importance of gas chromatography-mass spectrometry (GC-MS) for determination of steroids in man. The use of steroids labelled with stable isotopes as internal standard and subsequent analysis by GC-MS yields up to now the only reliable measurement of steroids in serum. Isotope dilution GC-MS is the reference method for evaluation of routine analysis of serum steroid hormones. GC-MS is an important tool for detection of steroid hormone doping and combined with a combustion furnace and an isotope ratio mass spectrometer the misuse of testosterone by athletes can be discovered. Finally the so called urinary steroid profile by GC and GC-MS is the method of choice for detection of steroid metabolites in health and disease.

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