Butyrycholinesterase K variant and Alzheimer's disease

J Neurol. 1999 May;246(5):369-70. doi: 10.1007/s004150050365.


This study attempted to corroborate findings on the association between butyrylcholinesterase K variant and Alzheimer's disease. This was performed on an autopsy-confirmed series of patients with Alzheimer's disease and controls. The butyrylcholinesterase K variant was found to be of increased allele frequency in patients with sporadic Alzheimer's disease. When related to APOE epsilon4 typing the association was specific but not sensitive for the diagnosis of Alzheimer's disease.

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Apolipoprotein E4
  • Apolipoproteins E / metabolism
  • Australia
  • Butyrylcholinesterase / genetics*
  • Butyrylcholinesterase / metabolism*
  • Female
  • Gene Frequency
  • Genetic Variation* / physiology
  • Genotype
  • Humans
  • Male


  • Apolipoprotein E4
  • Apolipoproteins E
  • Butyrylcholinesterase