[Level of nicotinamide coenzymes in the liver and myocardium of rats poisoned with dichlorethane]

Biull Eksp Biol Med. 1975 Apr;79(4):58-60.
[Article in Russian]


Experiments were conducted on male rats. A study was made of the content of nicotinamide coenzymes in the liver and myocardium 24 hours after the administration of 0.5 ml of dichloroethane into the stomach. In parallel with disturbance of the morphological structure of the liver and of the myocardium, increase in the activity of alanine and aspargic aminotranspherases in the blood serum, dichloroethane reduced the content of nicotinamide coenzymes and deranged the ratio of their oxidized and reduced forms in these organs.

Publication types

  • English Abstract

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Ethylene Dichlorides / poisoning*
  • Heart / drug effects
  • Hydrocarbons, Chlorinated / poisoning*
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Myocardium / metabolism*
  • NAD / metabolism*
  • NADP / metabolism*
  • Rats


  • Ethylene Dichlorides
  • Hydrocarbons, Chlorinated
  • NAD
  • NADP
  • Aspartate Aminotransferases
  • Alanine Transaminase