Angiotensin converting enzyme deletion allele in different kinds of dementia disorders

Neurosci Lett. 1999 May 28;267(2):97-100. doi: 10.1016/s0304-3940(99)00329-8.


In order to verify the association of Angiotensin converting enzyme (ACE) gene with different kinds of dementia, as well as its association with APO-E (genotype), we performed ACE genotyping in subjects with late-onset probable Alzheimer's disease (LOAD, n = 64), early-onset probable Alzheimer's disease (EOAD, n = 32), possible Alzheimer's disease (pAD, n = 44), vascular dementia (VD, n = 12), age-associated memory impairment (AAMI, n = 15) and 40 healthy age-matched controls, who were previously characterized for APO-E. After the principal component analysis ACE D and Apo-Eepsilon4 alleles disclosed the highest prevalence in the cognitively impaired groups of subjects, Apo-Eepsilon4 being more specific for LOAD and pAD. ACE D allele seems to be an unspecific susceptibility factor for mental decline.

MeSH terms

  • Age Factors
  • Age of Onset
  • Aged
  • Alleles*
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / genetics
  • Apolipoproteins E / metabolism
  • Dementia / enzymology
  • Dementia / genetics*
  • Female
  • Gene Deletion*
  • Genotype
  • Humans
  • Male
  • Memory Disorders / enzymology
  • Memory Disorders / genetics
  • Middle Aged
  • Peptidyl-Dipeptidase A / genetics*
  • Peptidyl-Dipeptidase A / metabolism


  • Apolipoproteins E
  • Peptidyl-Dipeptidase A