Expression of the coxsackievirus and adenovirus receptor in cultured human umbilical vein endothelial cells: regulation in response to cell density

J Virol. 1999 Aug;73(8):7077-9. doi: 10.1128/JVI.73.8.7077-7079.1999.


Primary cultures of human umbilical vein endothelial cells (HUVEC) express the human coxsackievirus and adenovirus receptor (HCAR). Whereas HCAR expression in HeLa cells was constant with respect to cell density, HCAR expression in HUVEC increased with culture confluence. HCAR expression in HUVEC was not quantitatively altered by infection with coxsackievirus B.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / metabolism*
  • Cell Count
  • Cells, Cultured
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Enterovirus / metabolism*
  • HeLa Cells
  • Humans
  • Receptors, Virus / biosynthesis*
  • Umbilical Veins


  • CLMP protein, human
  • Coxsackie and Adenovirus Receptor-Like Membrane Protein
  • Receptors, Virus