TNF-alpha and HLA-DR genotyping as potential prognostic markers in pulmonary sarcoidosis

Eur Cytokine Netw. 1999 Jun;10(2):143-6.


We have analyzed the HLA-DRB1 alleles and -308 TNF-alpha gene polymorphism in 78 sarcoidosis patients and 50 controls. The sarcoidosis group as a whole did not show any significant correlation with the TNF-A or the HLA-DR alleles compared to the control group. However, the patient subgroups of Löfgren and non-Löfgren sarcoidosis exhibited significant allele associations. In the Löfgren patient group, the TNF-A2 and the HLA-DR3 alleles were represented significantly higher, with a highly significant relative risk resulting from the presence of the TNF-A2 or the HLA-DR3 allele or both. In the non-Löfgren patient group, the phenotype expressing HLA-DR2 and lacking TNF-A2 was significantly higher than in the Löfgren patient group. Due to these significant genetic differences in the subgroups of Löfgren and non-Löfgren sarcoidosis patients, we conclude that the genotyping of these two loci (-308 TNF-alpha promoter polymorphism and HLA-DR) may be of prognostic value for the course of disease in sarcoidosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Alleles
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Prognosis
  • Promoter Regions, Genetic / genetics
  • Sarcoidosis, Pulmonary / classification
  • Sarcoidosis, Pulmonary / genetics*
  • Sarcoidosis, Pulmonary / immunology
  • Tumor Necrosis Factor-alpha / genetics*


  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Tumor Necrosis Factor-alpha