Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21

Am J Med Genet. 1999 Aug 20;88(4):348-51.


To determine the importance of a candidate gene KCNN3 (formerly named hSKCa3) in the susceptibility to schizophrenia, we have studied the genotypes of a (CAG)n polymorphism within this gene in the DNAs of the members of 54 multiplex families with this disease. Parametric and nonparametric linkage analysis did not provide evidence for linkage between KCNN3 (that we mapped to chromosome 1q21) and schizophrenia. Furthermore, we observed no difference in the distribution of the (CAG)n alleles between affected and normal individuals. These results do not support the hypothesis that larger KCNN3 alleles are preferentially associated with schizophrenia [Chandy et al. 1998 Mol Psychiatr 3:32-37] in individuals from multiply affected families.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Female
  • Genetic Linkage*
  • Genetic Markers
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic*
  • Potassium Channels / genetics*
  • Potassium Channels, Calcium-Activated*
  • Schizophrenia / genetics*
  • Small-Conductance Calcium-Activated Potassium Channels
  • Trinucleotide Repeats*


  • Genetic Markers
  • KCNN3 protein, human
  • Potassium Channels
  • Potassium Channels, Calcium-Activated
  • Small-Conductance Calcium-Activated Potassium Channels