Inhibition of aromatase activity by flavonoids

Arch Pharm Res. 1999 Jun;22(3):309-12. doi: 10.1007/BF02976369.


In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aromatase / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Evaluation
  • Female
  • Flavonoids / pharmacology*
  • Humans
  • Microsomes / enzymology*
  • Placenta / enzymology*
  • Pregnancy
  • Time Factors


  • Flavonoids
  • Aromatase