Multidrug resistance-associated protein subfamily transporters and drug resistance

Anticancer Drug Des. 1999 Apr;14(2):123-31.


Multidrug resistance-associated protein gene MRP/MRP1, and its family genes, including MRP2/cMOAT, have been isolated and characterized. These ATP-binding cassette (ABC) superfamily transporter genes are differentially expressed in various normal tissues and multidrug-resistant cell lines. Transfection of MRP/MRP1 and MRP2/cMOAT cDNA confers drug resistance on different spectra of anticancer agents from that of MDR1 coding P-glycoprotein. Although it remains unclear how MRP/MRP1 and related family genes are specifically involved in drug resistance in clinical cancers, current knowledge of the MRP subfamily suggests the importance of this class of transporters as a molecular target for drug sensitivity to anticancer agents.

Publication types

  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Animals
  • Anion Transport Proteins
  • Carrier Proteins / genetics*
  • Drug Resistance, Neoplasm / genetics*
  • Drug Resistance, Neoplasm / physiology
  • Genes, MDR / genetics*
  • Genes, MDR / physiology
  • Humans
  • Multidrug Resistance-Associated Proteins


  • ATP-Binding Cassette Transporters
  • Anion Transport Proteins
  • Carrier Proteins
  • Multidrug Resistance-Associated Proteins