Abstract
Fluoxetine-induced hepatotoxicity is generally considered of minimal clinical importance and is not well recognized. Asymptomatic increases in liver enzyme values have been observed in 0.5% of patients who take long-term fluoxetine therapy. This report details 2 cases of acute hepatitis believed to be caused by fluoxetine. Three cases of acute hepatitis caused by fluoxetine have been reported previously. The mechanism of fluoxetine-induced hepatotoxicity is unknown. Although routine monitoring of liver function may not be cost-effective, physicians should be alert to the possibility of fluoxetine-associated hepatitis and consider early discontinuation of the drug if this condition is suspected.
MeSH terms
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Acute Disease
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Adult
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Alanine Transaminase / blood
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Antidepressive Agents, Second-Generation / adverse effects*
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Antidepressive Agents, Second-Generation / therapeutic use
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Aspartate Aminotransferases / blood
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Bilirubin / blood
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Chemical and Drug Induced Liver Injury / blood
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Chemical and Drug Induced Liver Injury / diagnosis*
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Chemical and Drug Induced Liver Injury / etiology*
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Diagnosis, Differential
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Female
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Fluoxetine / adverse effects*
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Fluoxetine / therapeutic use
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Humans
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Male
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Middle Aged
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Selective Serotonin Reuptake Inhibitors / adverse effects*
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Selective Serotonin Reuptake Inhibitors / therapeutic use
Substances
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Antidepressive Agents, Second-Generation
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Serotonin Uptake Inhibitors
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Fluoxetine
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Aspartate Aminotransferases
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Alanine Transaminase
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Bilirubin