Progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus

J Rheumatol. 1999 Jul;26(7):1609-12.


We describe a patient with longstanding systemic lupus erythematosus (SLE) in remission who presented with recent onset neurological symptoms. Magnetic resonance imaging, followed by a brain biopsy and in situ hybridization, confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML). The clinical findings in this patient emphasize the importance of considering PML in an individual with SLE and neurological abnormalities.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biopsy
  • Female
  • Humans
  • In Situ Hybridization
  • Leukoencephalopathy, Progressive Multifocal / diagnostic imaging
  • Leukoencephalopathy, Progressive Multifocal / etiology*
  • Leukoencephalopathy, Progressive Multifocal / pathology
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / pathology
  • Magnetic Resonance Imaging
  • Radiography