Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues

L Yang; G Morriello; K Leung; T Jacks; K Cheng; K D Schleim; R Smith; A A Patchett

doi:10.1016/s0960-894x(99)00286-3

Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues

Bioorg Med Chem Lett. 1999 Jul 5;9(13):1761-6. doi: 10.1016/s0960-894x(99)00286-3.

Authors

L Yang¹, G Morriello, K Leung, T Jacks, K Cheng, K D Schleim, R Smith, A A Patchett

Affiliation

¹ Merck Research Laboratories, Rahway, NJ 07065, USA.

PMID: 10406638
DOI: 10.1016/s0960-894x(99)00286-3

Abstract

Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.

MeSH terms

Animals
Biological Availability
Dogs
Growth Hormone / chemical synthesis*
Growth Hormone / metabolism*
Models, Chemical
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Thiazoles / administration & dosage
Thiazoles / chemical synthesis*
Thiazoles / pharmacokinetics
Time Factors

Substances

Thiazoles
Growth Hormone