Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

Trends Cell Biol. 1999 Aug;9(8):319-23. doi: 10.1016/s0962-8924(99)01612-8.

Abstract

Interaction of cells with the extracellular matrix (ECM) results in the regulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achieve signalling by interacting with intracellular effectors that couple integrins and growth-factor receptors to downstream components. One well-studied effector is focal-adhesion kinase (FAK), but recently another protein kinase, integrin-linked kinase (ILK), has been identified as a receptor-proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and this provides new routes for integrin-mediated signalling. This article discusses ILK structure and function and recent genetic and biochemical evidence about the role of ILK in signal transduction.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Growth Substances / physiology*
  • Humans
  • Integrins / physiology*
  • Molecular Sequence Data
  • Protein Conformation
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / physiology*
  • Signal Transduction*
  • Structure-Activity Relationship

Substances

  • Growth Substances
  • Integrins
  • integrin-linked kinase
  • Protein-Serine-Threonine Kinases