Computing the Cox model for case cohort designs

Lifetime Data Anal. 1999 Jun;5(2):99-112. doi: 10.1023/a:1009691327335.


Prentice (1986) proposed a case-cohort design as an efficient subsampling mechanism for survival studies. Several other authors have expanded on these ideas to create a family of related sampling plans, along with estimators for the covariate effects. We describe how to obtain the proposed parameter estimates and their variance estimates using standard software packages, with SAS and S-Plus as particular examples.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anticoagulants / therapeutic use
  • Bandages
  • Case-Control Studies*
  • Cohort Studies
  • Computer Simulation*
  • Female
  • Heparin / therapeutic use
  • Humans
  • Male
  • Proportional Hazards Models*
  • Pulmonary Embolism / prevention & control
  • Software / statistics & numerical data*
  • Spinal Cord Injuries / physiopathology
  • Venous Thrombosis / etiology
  • Venous Thrombosis / physiopathology


  • Anticoagulants
  • Heparin