Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 354 (9173), 127-8

Venous Thromboembolism Among New Users of Different Oral Contraceptives

Comparative Study

Venous Thromboembolism Among New Users of Different Oral Contraceptives

R M Herings et al. Lancet.

Erratum in

  • Lancet 1999 Oct 23;354(9188):1478

Abstract

New use of third generation oral contraceptives is associated with a four-fold increased risk of venous thromboembolism compared with users of second generation oral contraceptives, particularly among young, healthy women.

PIP: This article focuses on venous thromboembolism (VTE) cases among oral contraceptive (OC) users. New use of third generation oral contraceptives is associated with a four-fold increased risk of VTE compared with the users of second generation OCs, particularly among young, healthy women. Data were obtained from the PHARMO system, which includes information of hospital admissions and drug dispensing for all 450,000 residents of 8 Dutch cities. The drug-dispensing record obtained from pharmacy files are complete, and are linked nationwide to the patient's hospital discharge records with a sensitivity and specificity of 95%. Samples included women aged 15-49 years without a history of prior VTE, oral anticoagulants, depot hormone preparations, cardiovascular drugs, the "morning after pill", or hospitalization for any reason in the 2 months before start of OC use. Results suggest that the difference in VTE risk between second and third generation OC is highest among the youngest women who use OC for the first time. However, it might be argued that among these young women, all those with an increased susceptibility for VTE are still present.

Comment in

  • Venous thromboembolism and oral contraceptives.
    Bloemenkamp KW, Rosendaal FR, Helmerhorst FM, Vandenbroucke JP. Bloemenkamp KW, et al. Lancet. 1999 Oct 23;354(9188):1469; author reply 1469-70. doi: 10.1016/S0140-6736(99)90187-3. Lancet. 1999. PMID: 10543689 No abstract available.
  • Venous thromboembolism and oral contraceptives.
    D'Souza R, Guillebaud J. D'Souza R, et al. Lancet. 1999 Oct 23;354(9188):1469; author reply 1469-70. doi: 10.1016/S0140-6736(05)77605-4. Lancet. 1999. PMID: 10543690 No abstract available.
  • Venous thromboembolism and oral contraceptives.
    Lewis MA, MacRae KD, Kühl-Habich D, Heinemann LA. Lewis MA, et al. Lancet. 1999 Oct 23;354(9188):1470. doi: 10.1016/S0140-6736(05)77607-8. Lancet. 1999. PMID: 10543691 No abstract available.

Similar articles

See all similar articles

Cited by 15 articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback