In patients with advanced oral cancer, a resection of the mandible continuity is often indicated. This new method presented here uses computer-aided design and manufacturing (CAD/CAM) for preoperative fabrication of individual mandibular prostheses and their corresponding resection templates in a direct fashion without the need for additional physical models. In this experimental application, a segment of a dried mandible was resected and replaced by a titanium prosthesis prefabricated by CAD/CAM. It was the aim of this investigation to verify the processing chain and its precision, i.e., the fit of an individual implant, such as this. Although this new technique offers fascinating opportunities, possible clinical drawbacks have to be taken into account.