The physical and psychological well-being of adults with Type 1 (insulin-dependent) diabetes (n = 397) were investigated using a series of questionnaires, including the Medical Outcomes Survey SF36. Development of diabetes complications and glycaemic control (glyated haemoglobin) were also measured. Results showed that older individuals, those with complications, women, the less physically active and those on lower incomes, were more likely to experience a poorer quality of life. Those who reported at least one hypoglycaemic episode per month also had poorer quality of life. This study, whilst confirming earlier work showing an association between quality of life and diabetes complications, demonstrates that other factors may also be important. Of particular interest is the association with hypoglycaemia, which has implications for diabetes care. Given the importance of reducing blood glucose levels in order to avoid complications, this focus in patient care may overlook the subsequent impact on quality of life.