Mobile gene cassettes and integrons in evolution

Ann N Y Acad Sci. 1999 May 18;870:68-80. doi: 10.1111/j.1749-6632.1999.tb08866.x.


Integrons and the site-specific recombination systems encoded by them provide a simple mechanism for the addition of new genes to bacterial chromosomes. Although there is substantial divergence among the four known integron-encoded integrases, they all recognize the recombination sites, known as 59-base elements, that are associated with genes that are packaged in gene cassettes. In contrast, the integron-associated recombination sites, attl sites, are preferentially recognized by the cognate integrase.

MeSH terms

  • Base Sequence
  • Binding Sites
  • DNA Transposable Elements*
  • Evolution, Molecular*
  • Integrases*
  • Molecular Sequence Data
  • Recombination, Genetic


  • DNA Transposable Elements
  • Integrases