Plasma agmatine and platelet imidazoline receptors in depression

Ann N Y Acad Sci. 1999 Jun 21;881:445-51. doi: 10.1111/j.1749-6632.1999.tb09392.x.

Abstract

Plasma agmatine concentrations are elevated significantly in depressed patients compared to healthy controls. Treatment with the antidepressant bupropion normalized plasma agmatine levels. Correlational evidence is presented that a change in plasma agmatine levels may lead to similar changes in platelet I1 imidazoline receptors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Agmatine / blood*
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Blood Platelets / metabolism*
  • Bupropion / therapeutic use
  • Cohort Studies
  • Depressive Disorder / blood*
  • Depressive Disorder / drug therapy
  • Humans
  • Imidazoles / pharmacokinetics
  • Imidazoline Receptors
  • Multivariate Analysis
  • Receptors, Drug / blood*
  • Reference Values

Substances

  • Antidepressive Agents, Second-Generation
  • Imidazoles
  • Imidazoline Receptors
  • Receptors, Drug
  • Bupropion
  • Agmatine