Deformation analysis to detect and quantify active lesions in three-dimensional medical image sequences

IEEE Trans Med Imaging. 1999 May;18(5):429-41. doi: 10.1109/42.774170.


Evaluating precisely the temporal variations of lesion volumes is very important for at least three types of practical applications: pharmaceutical trials, decision making for drug treatment or surgery, and patient follow-up. In this paper we present a volumetric analysis technique, combining precise rigid registration of three-dimensional (3-D) (volumetric) medical images, nonrigid deformation computation, and flow-field analysis. Our analysis technique has two outcomes: the detection of evolving lesions and the quantitative measurement of volume variations. The originality of our approach is that no precise segmentation of the lesion is needed but the approximative designation of a region of interest (ROI) which can be automated. We distinguish between tissue transformation (image intensity changes without deformation) and expansion or contraction effects reflecting a change of mass within the tissue. A real lesion is generally the combination of both effects. The method is tested with synthesized volumetric image sequences and applied, in a first attempt to quantify in vivo a mass effect, to the analysis of a real patient case with multiple sclerosis (MS).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Clinical Trials as Topic / methods
  • Clinical Trials as Topic / statistics & numerical data
  • Drug Evaluation / methods
  • Drug Evaluation / statistics & numerical data
  • Follow-Up Studies
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Image Processing, Computer-Assisted / statistics & numerical data
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging / statistics & numerical data
  • Multiple Sclerosis / diagnosis
  • Reproducibility of Results
  • Stochastic Processes
  • Surgical Procedures, Operative / methods
  • Surgical Procedures, Operative / statistics & numerical data
  • Time Factors